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Generic Name: Amlodipine 5mg + Atenolol 25mg
Manufacturer/Distributor: Drug International Limited
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✅ Description:
Indications of Amlocard Plus 25 Tablet
Use of Amlocard Plus 25 in the management of hypertension (high blood pressure). When one medication is ineffective, this is a combination of two medications that control blood pressure. Bringing down high blood pressure reduces the risk of future strokes and heart attacks.
Pharmacology of Amlocard Plus 25 Tablet
This fixed-dose combination of amlodipine and atenolol. a dihydropyridine calcium antagonist that inhibits calcium influx into both cardiac muscle and vascular smooth muscle, with vascular smooth muscle being more affected than cardiac muscle. Amlodipine is a peripheral vasodilator that works directly on vascular smooth muscle to lower blood pressure and peripheral vascular resistance. Amlodipine lowers afterload by reducing coronary vasoreactivity, coronary vasoreactivity, and tone, which reduces cardiac demand.
beta-blocker with cardioselectivity A beta-blocker is atenolol. A dose-dependent cardio-selectivity exists. By lowering cardiac output, plasma renin activity, and sympathetic outflow from the central nervous system, it lowers blood pressure (CNS). Myocardial oxygen demand is decreased as a result of atenolol's adverse inotropic and chronotropic effects.
Amlocard Plus 25 Tablet Dosage & Administration
- Adult: This therapy is started with a single dose of this preparation; however, titration of the dosage is advised depending on the therapeutic response.
- When treating elderly patients, it is recommended to start treatment with a fixed-dose combination of 2.5 mg of amlodipine and 25 mg of atenolol from a half-tablet.
Interaction of Amlocard Plus 25 Tablet
- This drug's 20% clearance is reduced by this medication. The possibility exists that the heart will experience cumulatively harmful inotropic effects.
- Ampicillin may reduce the concentrations of atenolol in doses of 1 gram and higher.
- Beta-blockers and oral antidiabetics might be related. Atenolol, in contrast, has a lower risk of these side effects.
Contraindications of Amlocard Plus 25 Tablet
Cardiogenic shock, hypotension, congestive heart failure, and poor left ventricular function are all symptoms of hypersensitivity to either component.
Amlocard Plus 25 Tablet Side Effects
Amlocard Plus 25 Tablets are well tolerated together. Anxiety or despair are some of the more common side effects.
Pregnancy & Lactation
To be utilized during pregnancy, the predicted benefit must outweigh the possible risks to a developing fetus. If you're a nursing mother, you shouldn't use this combo. Breastfeeding should be interrupted if it is deemed essential.
Precautions & Warnings
- With regard to patients with airway blockage, this combination should be utilized with caution.
- Patients with renal impairment can benefit from the combo. As a result of a probable reduction in the excretion of unaltered Atenolol, care is advised if your creatinine clearance is less than 30 ml/min.
- Due to the fact that Amlodipine's elimination half-life is prolonged in individuals with severe liver damage, caution should be used when using the combination.
- When it comes to drug withdrawal, patients should be reminded that coronary heart disease can develop without being identified.
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
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